Bioinformatics
aims at applying computer science methods to the affluence of data collected in
a variety of experiments in life sciences (e.g. cell and molecular biology,
biochemistry, medicine, etc.) in order
to help analysing such data and eliciting new knowledge from it.Read more
Structural Bioinformatics is a field, having its major aim to give computational approaches to predict and analyze the spatial structure of macromolecules like proteins, DNA, and RNA. Their 3D structure is predicted based on the 1D structure, the nucleotide or amino acid sequence, which is obtained from genome sequencing. Deliberating and understanding their 3D structure is crucial for inferring and modifying their function. Direct applications could be in medical and pharmacological fields especially for drug design, where it is important to determine which groups of ligands bind and regulate a protein, which proteins are potential targets for drugs, etc.
Promises of Structural Bioinformatics
Structural Bioinformatics is a field, having its major aim to give computational approaches to predict and analyze the spatial structure of macromolecules like proteins, DNA, and RNA. Their 3D structure is predicted based on the 1D structure, the nucleotide or amino acid sequence, which is obtained from genome sequencing. Deliberating and understanding their 3D structure is crucial for inferring and modifying their function. Direct applications could be in medical and pharmacological fields especially for drug design, where it is important to determine which groups of ligands bind and regulate a protein, which proteins are potential targets for drugs, etc.
Promises of Structural Bioinformatics
• creating an infrastructure for
building up structural models from component parts
• understanding structural basis
of biological phenomena (or differently put: understanding
structure-to- function principles)
• gaining the ability to
understand the design principles of proteins so that new functionalities can be
created
• learning how to design drugs
efficiently based on structural knowledge of their target
• catalyzing the development of
simulation models that can give insight into function based on structural
simulations by using computers…… Read more
 |
| Murrayaquinone B: 2D and 3D structure prepared in chemoffice. |
